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Drug Layering

Drug LayeringCentrifugal processing is single unit operation. The process involves the deposition of successive layers of an active compound onto nonpareil seeds resulting in the formation of uniform sized pellets. The operation is carried out using a plain rotating plate. During processing the starter seeds are wetted with a moistening liquid while rotating on the base plate. Dry powder dusted on nonpareils adheres, increasing their size and forming larger pellets. Growth occurs by a process of binding of powder/ liquid binding and consolidation. After liquid addition and dusting creates the correct diameter pellets, then tumbling of the coalesced aggregates increases their sphericity.

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